[UCI-Calit2] Calit2 Distinguished Lecture
Anna Lynn Spitzer
aspitzer at calit2.uci.edu
Fri Jan 11 11:53:02 PST 2008
Calit2 Distinguished Lecture
Please note the change in the originally announced date.
Title: Hidden Features of
Nucleotide Sequences Revealed by Genomic Signal Representation and
Processing
Speaker: Paul Cristea, University
"Politehnica" of Bucharest, Biomedical Engineering Center and the Vrije
Universiteit Brussel, Belgium
Time: 11 a.m.
Date: Friday, Jan. 18, 2008
Location: Calit2 Building, Room 3008
Abstract: The conversion of nucleotide sequences
into digital genomic signals allows using signal processing methods for
the analysis of genomic data. This approach reveals surprising
regularities in the distribution of nucleotides and pairs of
nucleotides, in both prokaryotes and eukaryotes. These structural and
statistical restrictions of genomic sequences would be difficult to
identify by using only statistical and pattern-matching methods, as in
standard symbolic sequence analysis. Long range regularities make the
structure of a genome less like that of a "plain text," which simply
conveys a semantics in accordance to a grammar, and more like that of a
"poem," which obeys additional structural rules that give "rhythm" and
"rhyme." A direct application of these regularities is predicting
nucleotides in a sequence when knowing the preceding ones, in a way
similar to time series prediction. This approach attempts to model
processes such as DNA replication, DNA transcription or mRNA
translation, and allows the possibility of low-level error correction.
Moreover, genomic signal analysis (GSA) reveals the hidden ancestral
structure of nucleotide sequences, before their re-structuring under the
selective pressure of species separation. GSA is also efficient in the
analysis of pathogen variability. This is important for the
molecular-level detection of mutations that induce drug resistance,
avoiding the lengthy and expensive phenotypic clinical studies
requesting pathogen culture.
Bio: Paul Cristea received degrees from
the University "Politehnica" of Bucharest, Romania in1962, and the
University of Bucharest in 1969 before earning a Ph.D. in technical
physics from the University "Politehnica" of Bucharest (UPB) in 1970.
Since then, his research and teaching activities have covered a variety
of topics, including digital signal and image processing, genomic
signals, neural and evolutionary systems, computerized medical
equipment, evolutionary intelligent agents and intelligent e-learning
environments. He has 11 patents, is the author or co-author of more than
130 published papers and has contributed to more than 20 books. Cristea
is currently affiliated with UPB, the Biomedical Engineering Center
(general director) and the Vrije Universiteit Brussel, Belgium. He is a
corresponding member of the Romanian Academy of Sciences and director of
the Romanian Bioinformatics Society.
Faculty Sponsor: Prof.Rui J. P. de Figueiredo
EECS and Math Departments
-------------- next part --------------
An HTML attachment was scrubbed...
URL: http://maillists.uci.edu/mailman/public/uci-calit2/attachments/20080111/926ea9f5/attachment.html
More information about the UCI-Calit2
mailing list